Chelsea will face fellow Premier League heavyweights Manchester City in the stand-out tie of the FA Cup fifth round.
In the draw for which was made on Sunday the London side booked their place in the last 16 with a 5-1 win at Milton Keynes Dons and were immediately dealt a home game against City, who won 4-0 at Aston Villa on Saturday.
Third-tier Shrewsbury Town, who shocked Championship side Sheffield Wednesday 3-2 in round four, were rewarded with a glamour tie at home to Manchester United.
Meanwhile, Arsenal, seeking a third consecutive FA Cup success, were handed a home tie against second-tier Hull City, who they defeated in the 2014 final.
Tottenham Hotspur will host London rivals Crystal Palace, while another all-Premier League tie sees Everton, 3-0 winners at fourth-tier Carlisle United on Sunday, visit Bournemouth.
English FA Cup fifth-round draw, made at Stadium MK in Milton Keynes on Sunday (ties to be played on February 20-21):
Chelsea v Manchester City
Reading v West Bromwich Albion or Peterborough United
Watford v Leeds United
Shrewsbury Town v Manchester United
Blackburn Rovers v Liverpool or West Ham United
Tottenham Hotspur v Crystal Palace
Arsenal v Hull City
Bournemouth v Everton