Four English teams will find out their potential route to the final of the Champions League when the quarter-final and semi-final draw takes place on Friday at 11:00 GMT.
Liverpool, Manchester City, Manchester United and Tottenham could face each other in the knockout stages.
Arsenal and Chelsea are in the Europa League quarter-final draw at 12:00 GMT.
It is the first time in 48 years that England has had six quarter-finalists in major European competitions.
The other four teams in the Champions League draw are Spanish champions Barcelona, Dutch four-time winners Ajax, Italian champions Juventus and Portuguese champions Porto.
It is the first time since 2009 that four English sides are in the last eight of the Champions League.
In Friday’s draw, Uefa will also pick the ‘home’ and ‘away’ sides for the final at Atletico Madrid’s Wanda Metropolitano stadium.
The last English side to win the competition was Chelsea 2012 ,although Liverpool made the final last season.
Manchester City and Manchester United cannot play at home on the same day or consecutive nights and therefore the team which finished lower in the Premier League last season – in this case United – will be forced to reverse the tie if they both draw home legs first.
The last meeting between two English sides took place last season when Liverpool knocked out Manchester City in the last eight.
The quarter-final first legs take place on 9 April and 10 April. The semi-finals start on 30 April and 1 May before the final on Saturday, 1 June.